Pyrethroid insecticide metabolites are associated with serum hormone levels in adult men.
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| Abstract |
Experimental studies have reported that pyrethroid insecticides affect male endocrine and reproductive function, but human data are limited. We recruited 161 men from an infertility clinic between years 2000-2003 and measured serum reproductive and thyroid hormone levels, as well as the pyrethroid metabolites 3-phenoxybenzoic acid (3PBA) and cis- and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis-DCCA and trans-DCCA) in spot urine samples. When adjusting for potential confounders, categories for all three metabolites, as well as their summed values, were positively associated with FSH (all p-values for trend <0.05). Statistically significant or suggestive positive relationships with LH were also found. In addition, cis-DCCA and trans-DCCA were inversely associated with inhibin B (p for trend=0.03 and 0.02, respectively). Finally, there was evidence that trans-DCCA was inversely associated with testosterone and free androgen index (the ratio of testosterone to sex hormone binding globulin; p for trend=0.09 and 0.05, respectively). The observed relationships were consistent with previous findings, but further research is needed for a better understanding of the potential association between pyrethroid insecticides and male reproduction.
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| Authors | John D Meeker, Dana B Barr, Russ Hauser |
| Journal | Reproductive toxicology (Elmsford, N.Y.) (Reprod Toxicol) Vol. 27 Issue 2 Pg. 155-60 (Apr 2009) ISSN: 0890-6238 [Print] United States |
| PMID | 19429394 (Publication Type: Journal Article, Research Support, N.I.H., Extramural) |
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