Abstract | AIM OF THE STUDY: MATERIALS AND METHODS:
Bisabolangelone was isolated from Angelica polymorpha Maxim collected from Shennongjia Forest District of China. The structure of bisabolangelone was elucidated by NMR and MS spectrums. The anti- ulcer effects were evaluated with length of lesion (mm) and activity of H(+)/K(+)- ATPase in two models induced by ethanol and Pylorus ligation. Experimental groups were administered with different doses of bisabolangelone (3.8, 7.6 and 15.3 mg/kg). The positive control group was administered omeprazole with a dose of 3.3 mg/kg. RESULTS:
Bisabolangelone significantly reduced the length of lesion (3.8, 7.6 and 15.3 mg/kg, P<0.01), inhibited the activity of H(+)/K(+)- ATPase (3.8, 7.6 and 15.3 mg/kg, P<0.01), decreased the volume of gastric juice (7.6 and 15.3 mg/kg, P<0.05), and increased the pH value of gastric juice (7.6 and 15.3 mg/kg, P<0.01, 3.8 mg/kg, P<0.05). CONCLUSIONS:
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Authors | Junzhi Wang, Liebin Zhu, Kun Zou, Fan Cheng, Feijun Dan, Zhiyong Guo, Zhengjun Cai, Jin Yang |
Journal | Journal of ethnopharmacology
(J Ethnopharmacol)
Vol. 123
Issue 2
Pg. 343-6
(Jun 22 2009)
ISSN: 1872-7573 [Electronic] Ireland |
PMID | 19429382
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Ulcer Agents
- Proton Pump Inhibitors
- Sesquiterpenes
- bisabolangelone
- Omeprazole
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Topics |
- Angelica
(chemistry)
- Animals
- Anti-Ulcer Agents
(administration & dosage, isolation & purification, pharmacology)
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Gastric Juice
(chemistry, drug effects)
- Hydrogen-Ion Concentration
(drug effects)
- Male
- Medicine, Chinese Traditional
- Mice
- Omeprazole
(pharmacology)
- Proton Pump Inhibitors
- Rats
- Rats, Sprague-Dawley
- Sesquiterpenes
(administration & dosage, isolation & purification, pharmacology)
- Stomach Ulcer
(drug therapy)
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