Efficacy of a novel Pasteurella multocida vaccine against progressive atrophic rhinitis of swine.

Abstract

The efficacy of a novel vaccine composed of three short recombinant subunit Pasteurella multocida toxin (PMT) proteins in combination with a bi-valent P. multocida whole-cell bacterin (rsPMT-PM) was evaluated in field studies for prevention and control of progressive atrophic rhinitis (PAR) of swine at 15 conventional farrow-to-finish farms. Experimental piglets that were immunized twice with the rsPMT-PM vaccine developed detectable titers of neutralizing antibodies (greater than 1:8) that prevented the growth retardation and pathological lesions typically observed following challenge with authentic PMT. A total of 542 sows were vaccinated once or twice prior to parturition and serum neutralizing antibody titers were evaluated. Both single and double vaccination protocols induced neutralizing antibody titers of 1:16 or higher in 62% and 74% of sows, respectively. Notably, neither sows nor piglets at a farm experiencing a severe outbreak of PAR at the time of the vaccination trial had detectable antibody titers, but antibody titers increased significantly to 1:16 or higher in 40% of sows following double vaccination. During the year after vaccination, clinical signs of PAR decreased in fattening pigs and growth performance improved sufficiently to reduce the rearing period until marketing by 2 weeks. Collectively, these results indicate that the rsPMT-PM vaccine could be used to provide protective immunity for controlling the prevalence and severity of PAR among farm-raised swine.

• Authors: Shih-Ling Hsuan, Chih-Ming Liao, Chienjin Huang, James R Winton, Zeng-Weng Chen, Wei-Cheng Lee, Jiunn-Wang Liao, Ter-Hsin Chen, Chwei-Jang Chiou, Kuang-Sheng Yeh, Maw-Sheng Chien
• Journal: Vaccine (Vaccine) Vol. 27 Issue 22 Pg. 2923-9 (May 14 2009) ISSN: 0264-410X [Print] Netherlands
• PMID: 19428902 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Bacterial
• Bacterial Vaccines
• Vaccines, Subunit

Topics

• Animals
• Antibodies, Bacterial (blood)
• Bacterial Vaccines (immunology)
• Immunization, Secondary
• Nasal Cavity (pathology)
• Neutralization Tests
• Pasteurella Infections (prevention & control)
• Pasteurella multocida (immunology)
• Rhinitis, Atrophic (microbiology, veterinary)
• Severity of Illness Index
• Swine (growth & development)
• Swine Diseases (microbiology, prevention & control)
• Vaccines, Subunit (immunology)