Poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL) nanoparticles for honokiol delivery in vitro.

Abstract

In this article, poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL, PCEC) nanoparticles were successfully prepared for honokiol delivery in vitro. Blank or honokiol loaded PCL-PEG-PCL nanoparticles were prepared in moderate condition by solvent diffusion method without using any surfactants. The prepared blank PCL-PEG-PCL nanoparticles are mono-dispersed and smaller than 200 nm. The particle size increased with increase in polymer concentration and oil-water (O/W) ratio. The prepared PCL-PEG-PCL nanoparticles (40 mg/mL, ca. 106 nm) did not induce hemolysis in vitro. And the 50% inhibiting concentration (IC50) of it (48 h) on HEK293 cells was higher than 5 mg/mL. Honokiol could be efficiently loaded into PCL-PEG-PCL nanoparticles and released from these nanoparticles in an extended period in vitro. After honokiol (HK) was entrapped into PCL-PEG-PCL nanoparticles, the particle size increased with the increase in HK/PCEC mass ratio in feed, and the encapsulated honokiol retained potent anticancer activity in vitro. The PCL-PEG-PCL nanoparticle was suitable for honokiol delivery, and such honokiol loaded PCL-PEG-PCL nanoparticle was a novel honokiol formulation.

• Authors: MaLing Gou, Lan Zheng, XinYun Peng, Ke Men, XiuLing Zheng, Shi Zeng, Gang Guo, Feng Luo, Xia Zhao, LiJuan Chen, YuQuan Wei, ZhiYong Qian
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 375 Issue 1-2 Pg. 170-6 (Jun 22 2009) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 19427143 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antineoplastic Agents, Phytogenic
• Biphenyl Compounds
• Drug Carriers
• Drugs, Chinese Herbal
• Lignans
• Polyesters
• Solvents
• poly(epsilon-caprolactone)-poly(oxyethylene)-poly(epsilon-caprolactone)
• honokiol
• Polyethylene Glycols

Topics

• Animals
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Biphenyl Compounds (administration & dosage)
• Cell Line
• Cell Line, Tumor
• Drug Carriers (chemistry)
• Drugs, Chinese Herbal (administration & dosage)
• Erythrocytes (drug effects, metabolism)
• Female
• Hemolysis (drug effects)
• Humans
• Lignans (administration & dosage)
• Nanoparticles
• Ovarian Neoplasms (drug therapy, pathology)
• Particle Size
• Polyesters (chemistry)
• Polyethylene Glycols (chemistry)
• Rabbits
• Solvents (chemistry)