Abstract | BACKGROUND: Malignant phyllodes tumors of the breast are unusual neoplasms, with an incidence of approximately 500 cases annually in the United States. Published local recurrence rates after margin-negative breast-conserving resections of borderline malignant and malignant phyllodes tumors are unacceptably high, at 24 and 20%, respectively. It is uncertain whether radiotherapy after resection of phyllodes tumors is beneficial. METHODS: We prospectively enrolled patients who were treated with a margin-negative breast-conserving resection of borderline malignant or malignant phyllodes tumors to adjuvant radiotherapy. The primary endpoint was local recurrence. RESULTS: Forty-six women were treated at 30 different institutions. The mean patient age was 49 years (range, 18-76 years). Thirty patients (65%) had malignant phyllodes tumors; the rest were borderline malignant. The mean tumor diameter was 3.7 cm (range, .8-11 cm). Eighteen patients had a negative margin on the first excision. The median size of the negative margin was .35 cm (range, <.1-2 cm). Twenty-eight patients underwent a re-excision because of positive margins in the initial resection. Two patients died of metastatic phyllodes tumor. During a median follow-up of 56 months (range, 12-129 months), none of the 46 patients developed a local recurrence (local recurrence rate, 0%; 95% confidence interval, 0-8). CONCLUSIONS:
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Authors | Richard J Barth Jr, Wendy A Wells, Sandra E Mitchell, Bernard F Cole |
Journal | Annals of surgical oncology
(Ann Surg Oncol)
Vol. 16
Issue 8
Pg. 2288-94
(Aug 2009)
ISSN: 1534-4681 [Electronic] United States |
PMID | 19424757
(Publication Type: Journal Article, Multicenter Study)
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Topics |
- Adolescent
- Adult
- Aged
- Breast Neoplasms
(pathology, radiotherapy)
- Female
- Humans
- Middle Aged
- Neoplasm Recurrence, Local
(diagnosis)
- Neoplasm Staging
- Phyllodes Tumor
(pathology, radiotherapy)
- Prognosis
- Prospective Studies
- Radiotherapy, Adjuvant
- Survival Rate
- Treatment Outcome
- Young Adult
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