CXCR3 expression on peripheral CD4+ T cells as a predictive marker of response to treatment in chronic hepatitis C.

Abstract	We monitored in fifty individuals with chronic hepatitis C (CHC) the expression of CCR5 and CXCR3, two chemokine receptors involved in the intra-hepatic recruitment of T cells, at the surface of circulating CD4+ T cells. The percentage of CD4+ T cells expressing CCR5 and/or CXCR3 was increased in patients. The increased percentage of CD4+ CXCR3+ T lymphocytes was linked to serum level of aspartate aminotransferase (AST) and to fibrosis METAVIR score. CD4+ T cell surface CCR5 and CXCR3 densities increased after 6 months of treatment with pegylated interferon-alpha and ribavirin. The pre-therapeutic percentage of CD4+ CXCR3+ T cells was correlated with alanine aminotransferase serum level at 12 months, and viral load at 24 months after treatment initiation. Thus, in CHC we observed a high CXCR3 expression on peripheral blood CD4+ T cells which correlates with AST serum level and liver fibrosis, and is predictive of the response to treatment.
Authors	Pascal Perney, Chrystell Turriere, Pierre Portalès, Hélène Rigole, Christina Psomas, François Blanc, Jacques Clot, Pierre Corbeau
Journal	Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 132 Issue 1 Pg. 55-62 (Jul 2009) ISSN: 1521-7035 [Electronic] United States
PMID	19423402 (Publication Type: Clinical Trial, Journal Article)
Chemical References	Antiviral Agents Biomarkers CXCR3 protein, human Interferon alpha-2 Interferon-alpha Receptors, CCR5 Receptors, CXCR3 Recombinant Proteins Polyethylene Glycols Ribavirin Aspartate Aminotransferases peginterferon alfa-2a
Topics	Adult Aged Antiviral Agents (therapeutic use) Aspartate Aminotransferases (blood) Biomarkers (analysis) CD4-Positive T-Lymphocytes (cytology, drug effects, metabolism) Drug Therapy, Combination Female Fibrosis Flow Cytometry Hepatitis C, Chronic (diagnosis, drug therapy, metabolism) Humans Interferon alpha-2 Interferon-alpha (therapeutic use) Liver (drug effects, pathology, virology) Male Middle Aged Polyethylene Glycols (therapeutic use) Predictive Value of Tests Prognosis Receptors, CCR5 (biosynthesis) Receptors, CXCR3 (biosynthesis) Recombinant Proteins Ribavirin (therapeutic use) Treatment Outcome Young Adult

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