| Abstract | A series of aromatic acetic acid compounds were designed and synthesized on the basis of Non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Compounds 5a, 7a, 5h, 7h and 17 could strongly promote insulin-regulated differentiation of 3T3-L1 cells in vitro. They acted as full or partial PPARgamma agonist, or improved insulin resistance through non-PPARgamma pathway. |
| Authors | Jiquan Zhang, Jianta Wang, Haoshu Wu, Yaoyao He, Gaofeng Zhu, Xing Cui, Lei Tang
(Affiliation: School of Pharmacy, Guiyang Medical College, Guiyang 550004, China.)
|
| Journal | Bioorganic & medicinal chemistry letters
(Bioorg Med Chem Lett)
Vol. 19
Issue 12
Pg. 3324-7
(Jun 15 2009)
ISSN: 1464-3405 [Electronic] England |
| PMID | 19423341
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
| Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cyclooxygenase Inhibitors
- PPAR gamma
- Insulin
- Diclofenac
- Indomethacin
|
| Topics |
- 3T3-L1 Cells
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(chemistry, pharmacology)
- Cell Differentiation
(drug effects)
- Cyclooxygenase Inhibitors
(chemistry, pharmacology)
- Diclofenac
(chemistry, pharmacology)
- Drug Design
- Indomethacin
(chemistry, pharmacology)
- Insulin
(pharmacology)
- Insulin Resistance
- Mice
- PPAR gamma
(agonists, metabolism)
- Rats
|
