A general and convenient catalytic synthesis of nitriles from amides and silanes.

Abstract

A new and convenient protocol for the catalytic dehydration of aromatic and aliphatic amides using silanes in the presence of catalytic amounts of fluoride is presented. The synthesis of aliphatic and aromatic nitriles proceeds with high selectivity under mild conditions. Notably, a wide substrate range is converted in good to excellent yields.

• Authors: Shaolin Zhou, Kathrin Junge, Daniele Addis, Shoubhik Das, Matthias Beller
• Journal: Organic letters (Org Lett) Vol. 11 Issue 11 Pg. 2461-4 (Jun 04 2009) ISSN: 1523-7052 [Electronic] United States
• PMID: 19422207 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amides
• Nitriles
• Quaternary Ammonium Compounds
• Silanes
• tetrabutylammonium

Topics

• Amides (chemistry)
• Catalysis
• Combinatorial Chemistry Techniques
• Molecular Structure
• Nitriles (chemical synthesis, chemistry)
• Quaternary Ammonium Compounds (chemistry)
• Silanes (chemistry)