Abstract | PURPOSE: Drusen are deposits located between the retinal pigment epithelium and Bruch's membrane in age-related maculopathy. They are believed to be photoreceptor byproducts that are incompletely metabolized by the retinal pigment epithelium. This study therefore compares the lectin histochemistry of drusen, photoreceptors, retinal pigment epithelium, and Bruch's membrane. METHODS: RESULTS: CONCLUSIONS: The results suggest that the pathogenesis of drusen is a combined mechanism, involving photoreceptors, Bruch's membrane, and the retinal pigment epithelium.
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Authors | Yvonne B D'Souza, Carolyn J P Jones, Richard E Bonshek |
Journal | Molecular vision
(Mol Vis)
Vol. 15
Pg. 906-11
( 2009)
ISSN: 1090-0535 [Electronic] United States |
PMID | 19421409
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lectins
- Biotin
- Neuraminidase
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Topics |
- Biotin
(metabolism)
- Bruch Membrane
(metabolism, ultrastructure)
- Histocytochemistry
- Humans
- Lectins
(metabolism)
- Macular Degeneration
- Neuraminidase
(metabolism)
- Photoreceptor Cells, Vertebrate
(metabolism, ultrastructure)
- Protein Binding
- Retinal Drusen
(metabolism)
- Retinal Pigment Epithelium
(metabolism, ultrastructure)
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