HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Characteristics, formation, and pathophysiology of glucosepane: a major protein cross-link.

Abstract
Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has been shown to accumulate in the extracellular matrix, where it cross-links collagen. Levels of glucosepane increase with aging. By increasing collagen stiffness, glucosepane cross-links may have significant implications in several age-related diseases, such as cardiovascular disease, diabetes, and osteoporosis. Although the formation pathways for glucosepane are relatively well researched, much is still unknown about the accumulation and pathophysiology of glucosepane.
AuthorsJohan Svantesson Sjöberg, Sven Bulterijs
JournalRejuvenation research (Rejuvenation Res) Vol. 12 Issue 2 Pg. 137-48 (Apr 2009) ISSN: 1557-8577 [Electronic] United States
PMID19415980 (Publication Type: Journal Article, Review)
Chemical References
  • Cross-Linking Reagents
  • Glycation End Products, Advanced
  • glucosepane
  • Collagen
  • Glucose
Topics
  • Aging (metabolism)
  • Animals
  • Collagen (chemistry, metabolism)
  • Cross-Linking Reagents (metabolism)
  • Disease
  • Glucose (metabolism)
  • Glycation End Products, Advanced (chemistry, metabolism)
  • Humans

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: