Abstract |
Advanced glycation end products are the results of a series of chemical reactions collectively known as the Maillard reaction, or nonenzymatic glycation, and sometimes cross-link proteins, thereby impairing their normal function. Glucosepane is the most abundant protein cross-link found in vivo so far and mainly has been shown to accumulate in the extracellular matrix, where it cross-links collagen. Levels of glucosepane increase with aging. By increasing collagen stiffness, glucosepane cross-links may have significant implications in several age-related diseases, such as cardiovascular disease, diabetes, and osteoporosis. Although the formation pathways for glucosepane are relatively well researched, much is still unknown about the accumulation and pathophysiology of glucosepane.
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Authors | Johan Svantesson Sjöberg, Sven Bulterijs |
Journal | Rejuvenation research
(Rejuvenation Res)
Vol. 12
Issue 2
Pg. 137-48
(Apr 2009)
ISSN: 1557-8577 [Electronic] United States |
PMID | 19415980
(Publication Type: Journal Article, Review)
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Chemical References |
- Cross-Linking Reagents
- Glycation End Products, Advanced
- glucosepane
- Collagen
- Glucose
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Topics |
- Aging
(metabolism)
- Animals
- Collagen
(chemistry, metabolism)
- Cross-Linking Reagents
(metabolism)
- Disease
- Glucose
(metabolism)
- Glycation End Products, Advanced
(chemistry, metabolism)
- Humans
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