Hypercalcemia in pediatric acute megakaryocytic leukemia: case report and review of the literature.

Abstract

Hypercalcemia has been described as a possible complication of many pediatric malignancies. Here, we report an 8-month-old non-Down syndrome infant with acute megakaryocytic leukemia and severe hypercalcemia at presentation. A review of the literature reveals that this is the first case of hypercalcemia complicating acute megakaryocytic leukemia reported in the pediatric literature. His initial workup, and the course of management and outcome, is described in detail. Though the etiology of this complication remains unclear, our experience suggests that early institution of chemotherapy along with supportive care is the best treatment for control of hypercalcemia.

• Authors: Muna Qayed, Ibrahim Ahmed, Rudolph P Valentini, Barbara Cushing, Madhvi Rajpurkar
• Journal: Journal of pediatric hematology/oncology (J Pediatr Hematol Oncol) Vol. 31 Issue 5 Pg. 373-6 (May 2009) ISSN: 1536-3678 [Electronic] United States
• PMID: 19415024 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Bone Density Conservation Agents
• Diphosphonates
• Pamidronate

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Bone Density Conservation Agents (administration & dosage)
• Bone Diseases, Metabolic (diagnostic imaging, drug therapy, etiology)
• Diphosphonates (administration & dosage)
• Humans
• Hypercalcemia (etiology, therapy)
• Infant
• Leukemia, Megakaryoblastic, Acute (complications, drug therapy)
• Male
• Pamidronate
• Radiography