Activity of SQ641, a capuramycin analog, in a murine model of tuberculosis.

Abstract	New delivery vehicles and routes of delivery were developed for the capuramycin analogue SQ641. While this compound has remarkable in vitro potency against Mycobacterium tuberculosis, it has low solubility in water and poor intracellular activity. We demonstrate here that SQ641 dissolved in the water-soluble vitamin E analogue alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) or incorporated into TPGS-micelles has significant activity in a mouse model of tuberculosis.
Authors	Boris V Nikonenko, Venkata M Reddy, Marina Protopopova, Elena Bogatcheva, Leo Einck, Carol A Nacy
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 53 Issue 7 Pg. 3138-9 (Jul 2009) ISSN: 1098-6596 [Electronic] United States
PMID	19414567 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)
Chemical References	Aminoglycosides Antitubercular Agents capuramycin Vitamin E tocophersolan
Topics	Aminoglycosides (chemistry, therapeutic use) Animals Antitubercular Agents (chemistry, therapeutic use) Disease Models, Animal Female Mice Mice, Inbred C57BL Mycobacterium tuberculosis (drug effects, physiology) Solubility Tuberculosis (drug therapy) Vitamin E (chemistry)

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