Inflamed snail speeds metastasis.

Abstract

Macrophage infiltration and inflammatory cytokines are powerful drivers of tumorigenesis and metastasis. Wu et al., in this issue of Cancer Cell, show that TNFalpha-dependent NFkappaB activation induces COP9 signalosome-mediated inhibition of GSK3beta and the SCF(beta-TRCP) ubiquitin ligase, thus leading to stabilization of the transcription factor Snail and promoting cell migration and metastasis.

• Authors: Chih-Cheng Yang, Dieter A Wolf
• Journal: Cancer cell (Cancer Cell) Vol. 15 Issue 5 Pg. 355-7 (May 05 2009) ISSN: 1878-3686 [Electronic] United States
• PMID: 19411063 (Publication Type: Journal Article, Comment)

Chemical References

• Multiprotein Complexes
• NF-kappa B
• Snail Family Transcription Factors
• Transcription Factors
• Tumor Necrosis Factor-alpha
• SKP Cullin F-Box Protein Ligases
• GSK3B protein, human
• Glycogen Synthase Kinase 3 beta
• Glycogen Synthase Kinase 3
• Peptide Hydrolases
• COP9 Signalosome Complex

Topics

• Animals
• COP9 Signalosome Complex
• Cell Movement (physiology)
• Cell Transformation, Neoplastic (metabolism)
• Glycogen Synthase Kinase 3 (antagonists & inhibitors)
• Glycogen Synthase Kinase 3 beta
• Humans
• Inflammation (metabolism)
• Macrophages (metabolism, pathology)
• Multiprotein Complexes (metabolism)
• NF-kappa B (metabolism)
• Neoplasm Metastasis
• Peptide Hydrolases (metabolism)
• SKP Cullin F-Box Protein Ligases (antagonists & inhibitors)
• Signal Transduction
• Snail Family Transcription Factors
• Transcription Factors (metabolism)
• Tumor Necrosis Factor-alpha (metabolism)