Abstract | BACKGROUND: METHODS AND RESULTS: Parameters recorded at baseline included vital signs, risk factors, medical history, and concomitant treatments, as well as stroke subtype, stroke-associated disability on the modified Rankin scale, and scores on scales for cognitive function and dependency. Eight hundred and two centers in 46 countries recruited a total of 19,119 patients between February 2006 and April 2008. The population is evenly distributed and is not dominated by any one country or region. The mean +/- SD age was 67.2 +/- 7.9 years, 63% were male, and 83% Caucasian; 83% had hypertension, and about half the population smoked or had quit smoking. Ninety percent of the qualifying events were ischemic stroke, 67% of which were classified as atherothrombotic or likely atherothrombotic (pure or coexisting with another cause). Modified Rankin scale scores showed slight or no disability in 83% of the population, while the scores on the Mini-Mental State Examination, Isaacs' Set Test, Zazzo's Cancellation Test, and the instrumental activities of daily living scale showed a good level of cognitive function and autonomy. CONCLUSIONS:
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Authors | M G Bousser, P Amarenco, A Chamorro, M Fisher, I Ford, K Fox, M Hennerici, H P Mattle, P M Rothwell, PERFORM Study Investigators |
Journal | Cerebrovascular diseases (Basel, Switzerland)
(Cerebrovasc Dis)
Vol. 27
Issue 6
Pg. 608-13
( 2009)
ISSN: 1421-9786 [Electronic] Switzerland |
PMID | 19407444
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Naphthalenes
- Platelet Aggregation Inhibitors
- Propionates
- Receptors, Thromboxane
- terutroban
- Aspirin
|
Topics |
- Activities of Daily Living
- Aged
- Aspirin
(therapeutic use)
- Cognition
(physiology)
- Diabetes Complications
(complications)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Female
- Humans
- Hypertension
(complications)
- International Cooperation
- Ischemic Attack, Transient
(epidemiology, physiopathology, prevention & control)
- Male
- Middle Aged
- Naphthalenes
(therapeutic use)
- Platelet Aggregation Inhibitors
(therapeutic use)
- Propionates
(therapeutic use)
- Receptors, Thromboxane
(antagonists & inhibitors)
- Risk Factors
- Secondary Prevention
- Severity of Illness Index
- Stroke
(epidemiology, physiopathology, prevention & control)
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