Abstract | OBJECTIVES: METHODS: KEY FINDINGS: After 7-9 days of treatment, sodium houttuyfonate significantly reduced the left ventricular weight index and heart weight index in mice and rats with myocardial hypertrophy, decreased the size of cardiomyocytes in rats, and reduced the content of cAMP and angiotensin II in mice with myocardial hypertrophy. It also decreased the endothelin-1 concentration and the hydroxyproline content in ventricular tissue in rats. CONCLUSIONS:
|
Authors | Jian Ping Gao, Chang Xun Chen, Ying Wang, Jian Lü, Wei Liang Gu |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 61
Issue 5
Pg. 677-83
(May 2009)
ISSN: 0022-3573 [Print] England |
PMID | 19406008
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Alkanes
- Endothelin-1
- Sulfites
- sodium houttuyfonate
- Angiotensin II
- Captopril
- Cyclic AMP
- Isoproterenol
- Thyroxine
- Hydroxyproline
|
Topics |
- Alkanes
(pharmacology)
- Angiotensin II
(metabolism, pharmacology)
- Animals
- Captopril
(pharmacology)
- Cardiomegaly
(chemically induced, pathology, prevention & control)
- Cyclic AMP
(blood)
- Dose-Response Relationship, Drug
- Endothelin-1
(metabolism)
- Hydroxyproline
(metabolism)
- Isoproterenol
- Male
- Mice
- Myocardium
(metabolism, pathology)
- Myocytes, Cardiac
(drug effects, pathology)
- Organ Size
(drug effects)
- Rats
- Rats, Sprague-Dawley
- Sulfites
(pharmacology)
- Thyroxine
|