HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Efficacy of micafungin in treating four premature infants with candidiasis.

AbstractBACKGROUND:
Although clinical experience in neonates with candidiasis exists for amphotericin B and fluconazole, these standard treatments are often hindered by drug-associated toxicity or development of resistant strains. The aim of the present study was therefore to investigate the efficacy and tolerability of a new antifungal agent, micafungin (MCFG), for treating Candida infections in premature infants.
METHODS:
This was a retrospective cohort study. Premature infants diagnosed with Candida infections from October 2003 to July 2004 were brought to the neonatal intensive care unit at the Center of Perinatal Medicine, Nara Medical University Hospital. Four newborns were given 0.5-1.0 mg/kg per day micafungin.
RESULTS:
Four premature infants (mean +/- SD gestational age, 24.1 +/- 0.9 weeks; mean +/- SD birthweight, 579.3 +/- 80.5 g) experienced complications from Candida infection; two cases of the fungal infection were caused by Candida glabrata and two cases were caused by Candida albicans. MCFG was administered at 0.5 or 1.0 mg/kg per day (mean dosage days, 9.8 +/- 3.1 days) and it decreased beta-D-glucan levels while improving clinical symptoms in all cases. Additionally, there were no apparent side-effects.
CONCLUSION:
MCFG is both effective and tolerable for use in premature infants suffering from Candida infections.
AuthorsChiharu Kawaguchi, Ikuyo Arai, Hajime Yasuhara, Reiko Sano, Toshiya Nishikubo, Yukihiro Takahashi
JournalPediatrics international : official journal of the Japan Pediatric Society (Pediatr Int) Vol. 51 Issue 2 Pg. 220-4 (Apr 2009) ISSN: 1442-200X [Electronic] Australia
PMID19405920 (Publication Type: Journal Article)
Chemical References
  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • beta-Glucans
  • Micafungin
Topics
  • Antifungal Agents (therapeutic use)
  • Candidiasis (blood, drug therapy)
  • Echinocandins (therapeutic use)
  • Female
  • Humans
  • Infant, Extremely Low Birth Weight
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases (drug therapy)
  • Lipopeptides (therapeutic use)
  • Male
  • Micafungin
  • Retrospective Studies
  • Treatment Outcome
  • beta-Glucans (blood)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: