Fesoterodine.

Abstract

black triangle Fesoterodine is a muscarinic receptor antagonist that is rapidly and extensively converted to the active and more potent metabolite 5-hydroxymethyltolterodine. The drug is approved for once-daily oral administration in patients with overactive bladder syndrome (OAB). black triangle In two large, 12-week, randomized, double-blind, multicentre, phase III trials, oral fesoterodine 4 or 8 mg once daily improved the symptoms of OAB (frequency of micturition, urgency and urge incontinence) significantly more than placebo. black triangle Furthermore, significantly more patients receiving fesoterodine 4 or 8 mg once daily had a positive response to therapy than those receiving placebo, as determined by a treatment questionnaire. black triangle Health-related quality of life was improved to a significantly greater extent in patients with OAB who received fesoterodine 4 or 8 mg once daily than in those who received placebo in a post hoc analysis of pooled data from the phase III trials. black triangle Fesoterodine 4 or 8 mg once daily was generally well tolerated in patients with OAB; the most frequent adverse event was dry mouth, which was generally mild to moderate in severity.

• Authors: Kate McKeage, Gillian M Keating
• Journal: Drugs (Drugs) Vol. 69 Issue 6 Pg. 731-8 ( 2009) ISSN: 0012-6667 [Print] New Zealand
• PMID: 19405552 (Publication Type: Journal Article, Review)

Chemical References

• Benzhydryl Compounds
• Muscarinic Antagonists
• fesoterodine

Topics

• Benzhydryl Compounds (adverse effects, pharmacology, therapeutic use)
• Humans
• Muscarinic Antagonists (adverse effects, pharmacology, therapeutic use)
• Randomized Controlled Trials as Topic
• Treatment Outcome
• Urinary Bladder, Overactive (drug therapy)