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[Diagnostic utility of anti-cyclic citrullinated peptide antibody in early rheumatoid arthritis].

Abstract
Current therapeutic strategies against rheumatoid arthritis (RA) employ increasingly aggressive regimens from an early stage of the disease ; thus, serological markers more specific than IgM-rheumatoid factor (IgM-RF) are desirable. Anti-cyclic citrullinated peptide (anti-CCP) antibody has been reported as a useful and highly specificity marker for the diagnosis of RA. To clarify the diagnostic utility of anti-CCP antibody in early RA, we measured serum concentrations of anti-CCP antibody, IgM-RF, anti-agalactosyl IgG antibody and matrix metalloproteinase (MMP)-3 in 184 polyarthritis patients who showed onset symptoms within the previous 2 years. The diagnostic sensitivity of anti-CCP antibody in early RA was 60.0%, equivalent to IgM-RF (66.3%) and anti-agalactosyl IgG antibody (66.0%). Specificity, positive predictive values and diagnostic accuracy of anti-CCP antibody were the best among the four tested makers. In 38 patients who initially did not meet the ACR criteria for RA, but were diagnosed with RA during the course, the diagnostic sensitivity of anti-CCP antibody was 55.3%. On the other hand, the disease activity score (DAS) 28 of anti-CCP antibody positive and the negative patients was 5.16 and 5.34, respectively. Our data indicated that determination of anti-CCP antibody was useful for early diagnosis of RA.
AuthorsTomoya Miyamura, Hideyuki Watanabe, Soichiro Takahama, Koshiro Sonomoto, Masataka Nakamura, Hitosi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu
JournalNihon Rinsho Men'eki Gakkai kaishi = Japanese journal of clinical immunology (Nihon Rinsho Meneki Gakkai Kaishi) Vol. 32 Issue 2 Pg. 102-9 (Apr 2009) ISSN: 1349-7413 [Electronic] Japan
PMID19404008 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Antibodies
  • Peptides, Cyclic
  • cyclic citrullinated peptide
Topics
  • Antibodies (blood)
  • Arthritis (diagnosis)
  • Arthritis, Rheumatoid (diagnosis)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Peptides, Cyclic (immunology)
  • Sensitivity and Specificity

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