HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Fibrils of prostatic acid phosphatase fragments boost infections with XMRV (xenotropic murine leukemia virus-related virus), a human retrovirus associated with prostate cancer.

Abstract
The xenotropic murine leukemia virus-related virus (XMRV) has recently been detected in prostate cancer tissues and may play a role in tumorigenesis. It is currently unclear how this virus is transmitted and which factors promote its spread in the prostate. We show that amyloidogenic fragments known as semen-derived enhancer of virus infection (SEVI) originating from prostatic acid phosphatase greatly increase XMRV infections of primary prostatic epithelial and stromal cells. Hybrid simian/human immunodeficiency chimeric virus particles pseudotyped with XMRV envelope protein were used to demonstrate that the enhancing effect of SEVI, or of human semen itself, was at the level of viral attachment and entry. SEVI enhanced XMRV infectivity but did not bypass the requirement for the xenotropic and polytropic retrovirus receptor 1. Furthermore, XMRV RNA was detected in prostatic secretions of some men with prostate cancer. The fact that the precursor of SEVI is produced in abundance by the prostate indicates that XMRV replication occurs in an environment that provides a natural enhancer of viral infection, and this may play a role in the spread of this virus in the human population.
AuthorsSeunghee Hong, Eric A Klein, Jaydip Das Gupta, Kirsten Hanke, Christopher J Weight, Carvell Nguyen, Christina Gaughan, Kyeong-Ae Kim, Norbert Bannert, Frank Kirchhoff, Jan Munch, Robert H Silverman
JournalJournal of virology (J Virol) Vol. 83 Issue 14 Pg. 6995-7003 (Jul 2009) ISSN: 1098-5514 [Electronic] United States
PMID19403677 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Acid Phosphatase
  • prostatic acid phosphatase
  • Protein Tyrosine Phosphatases
Topics
  • Acid Phosphatase
  • Cell Line, Tumor
  • Cells, Cultured
  • Fibroblasts (enzymology, virology)
  • Gammaretrovirus (genetics, physiology)
  • Humans
  • Male
  • Prostatic Neoplasms (enzymology, virology)
  • Protein Tyrosine Phosphatases (genetics, metabolism)
  • Retroviridae Infections (enzymology, virology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: