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Complete remission of OC-resistant catamenial shoulder joint pain and inguinal pain associated with extraperitoneal endometriosis following personalized GnRH agonist therapy.

AbstractBACKGROUND:
Patients with severe extraperitoneal endometriosis require rapid remission and cannot wait for the effects of oral contraceptive hormones (OCs) to appear.
CASE:
We successfully achieved personalized gonadotropin-releasing hormone agonist (GnRHa) therapy for a patient with catamenial right shoulder joint pain and right inguinal pain associated with extraperitoneal endometriosis, which was completely unable to be suppressed by OCs. A total of 15 subcutaneous GnRHa depot injections over a period of 19 months was performed according to the serum estradiol and LH levels, in order to maintain long-term amenorrhea without any estrogen-deprivation effects. No recurrence of the catamenial symptoms has been observed for more than 35 months after the final GnRHa depot injection.
CONCLUSION:
Personalized GnRHa therapy should become the first-choice therapy for OC-resistant inoperable extraperitoneal endometriosis.
AuthorsT Tanaka, N Umesaki
JournalClinical and experimental obstetrics & gynecology (Clin Exp Obstet Gynecol) Vol. 36 Issue 1 Pg. 46-8 ( 2009) ISSN: 0390-6663 [Print] Italy
PMID19400418 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Fertility Agents, Female
  • Gonadotropin-Releasing Hormone
  • Leuprolide
Topics
  • Endometriosis (complications, drug therapy, pathology)
  • Female
  • Fertility Agents, Female (administration & dosage)
  • Gonadotropin-Releasing Hormone (agonists)
  • Humans
  • Inguinal Canal (pathology)
  • Injections, Subcutaneous
  • Leuprolide (administration & dosage)
  • Middle Aged
  • Shoulder Pain (drug therapy, etiology)

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