Abstract | BACKGROUND: STUDY DESIGN: SETTINGS & PARTICIPANTS: 232 consenting long-term hemodialysis patients in 4 satellite dialysis units to a large dialysis program with protocolized treatment and targets. All patients were using twin- catheter single-lumen Tesio-Caths (MedComp, Harleysville, PA). INTERVENTION: OUTCOMES & MEASUREMENTS: RESULTS:
Catheter-related bacteremia did not differ in the 2 groups, with an incidence of 0.7 events/1,000 catheter-days. There was no significant difference in rates of exit-site infection (0.7 versus 0.5 events/1,000 catheter-days; P = 0.5). The secondary end point of catheter thrombosis defined by the use of a urokinase lock was significantly more common in the citrate group, with an incidence of 8 versus 4.3/1,000 catheter-days (P < 0.001). Other secondary end points did not differ. Citrate treatment was curtailed compared with heparin because of a greater incidence of adverse events, with a mean treatment duration before withdrawal of 4.8 +/- 2.0 versus 5.7 +/- 1.2 months, respectively (P < 0.001). LIMITATIONS: Low baseline catheter-related bacteremia and exit-site infection event rates may have underpowered this study. High adverse-event rates may have been related to high-concentration citrate that led to increased overspill and reduction in lock volume. This may also explain the increased rates of thrombosis in this group. CONCLUSION: Widespread and long-term use of 46.7% citrate catheter locks with Tesio-Cath access is not justified by this study.
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Authors | Albert Power, Neill Duncan, Seema K Singh, Wendy Brown, Elizabeth Dalby, Claire Edwards, Kathleen Lynch, Virginia Prout, Tom Cairns, Megan Griffith, Adam McLean, Andrew Palmer, David Taube |
Journal | American journal of kidney diseases : the official journal of the National Kidney Foundation
(Am J Kidney Dis)
Vol. 53
Issue 6
Pg. 1034-41
(Jun 2009)
ISSN: 1523-6838 [Electronic] United States |
PMID | 19394731
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Citrates
- Sodium Citrate
- Heparin
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Topics |
- Aged
- Bacteremia
(epidemiology, etiology, prevention & control)
- Catheterization, Central Venous
(adverse effects, instrumentation)
- Catheters, Indwelling
(adverse effects, microbiology)
- Citrates
(administration & dosage)
- Female
- Heparin
(administration & dosage)
- Humans
- Kidney Failure, Chronic
(epidemiology, microbiology, therapy)
- Male
- Middle Aged
- Renal Dialysis
(adverse effects, instrumentation)
- Sodium Citrate
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