Topical treatment of toxic epidermal necrolysis with Iodoplex.

Abstract

Toxic epidermal necrolysis (TEN) is characterized by extensive exfoliation of the epidermis, mucosal ulcerations and fever, after a recent intake of a new drug. TEN developed in an 8-year-old girl after she ingested sulfonamides and sustained skin injuries of 90% total body surface area. In addition to her critical care management, local treatment consisted of Iodoplex cream (Biosearch Laboratories, Haifa, Israel), a long-acting antimicrobial agent from which iodine is slowly released over 48 hours. Healing was observed within 8 to 17 days after initial application. Iodoplex cream is an additional topical agent for the local treatment of TEN when porcine heterografts or allografts might not be feasible.

• Authors: T Kaufman, H Shechter, G Bar-Joseph, B Hirshowitz
• Journal: The Journal of burn care & rehabilitation (J Burn Care Rehabil) 1991 Jul-Aug Vol. 12 Issue 4 Pg. 346-8 ISSN: 0273-8481 [Print] United States
• PMID: 1939307 (Publication Type: Case Reports, Journal Article)

Chemical References

• Acrylic Resins
• Anti-Infective Agents
• Ointments
• Iodine
• Iodoplex
• Povidone

Topics

• Acrylic Resins (therapeutic use)
• Administration, Cutaneous
• Anti-Infective Agents (therapeutic use)
• Child
• Female
• Humans
• Iodine (therapeutic use)
• Ointments
• Povidone (therapeutic use)
• Stevens-Johnson Syndrome (drug therapy, pathology)