MHC class I chain-related gene A transmembrane polymorphism in Spanish women with breast cancer.

Abstract

The NKG2D-major histocompatibility complex class I-related chain A (MICA) system plays a key role in the antitumoral immune response. We studied five alleles of a microsatellite in the MICA transmembrane region; one of which (MICA-A5.1) gives rise to a truncated protein. The MICA-A5 allele was reduced in breast cancer patients compared with healthy controls (P = 0.04). Given the association between the HLA-B7 allele and the susceptibility to breast cancer in our area, we also analyzed the distribution of the frequency of the MICA alleles in human leukocyte antigen (HLA)-B7 patients compared with patients with the other alleles. The MICA-A5.1 allele was increased in HLA-B7 patients (P = 0.0003). These results suggest that the MICA-A5 allele appears to confer protection against human breast cancer and that the MICA-A5.1 appears to increase the susceptibility to breast cancer in HLA-B7 patients in our area.

• Authors: R Lavado-Valenzuela, M Benavides, F Carabantes, A Alonso, A Caballero
• Journal: Tissue antigens (Tissue Antigens) Vol. 74 Issue 1 Pg. 46-9 (Jul 2009) ISSN: 1399-0039 [Electronic] England
• PMID: 19392799 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• HLA-B7 Antigen
• Histocompatibility Antigens Class I
• MHC class I-related chain A

Topics

• Alleles
• Breast Neoplasms (epidemiology, genetics)
• Exons (genetics)
• Female
• Gene Frequency (genetics)
• Genetic Predisposition to Disease
• HLA-B7 Antigen (genetics)
• Histocompatibility Antigens Class I (genetics)
• Humans
• Microsatellite Repeats (genetics)
• Polymorphism, Genetic
• Spain (epidemiology)