Cortical expression of prolactin (PRL), growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is not increased in experimental traumatic brain injury.

Abstract

BACKGROUND:

Cerebral cortical expression of the pituitary hormones prolactin (PRL) and growth hormone (GH) have reported in ischemic damage. Both hormones may be involved in vascular tone regulation and angiogenesis, and growth hormone is thought to be neuroprotective while prolactin stimulates astrogliosis.

METHODS:

We examined expression of prolactin, growth hormone and adrenocorticotrophic hormone (ACTH) using tissue microarray technology in the controlled cortical impact model of traumatic brain injury (TBI).

FINDINGS:

No increased expression of these hormones was seen.

CONCLUSIONS:

Unlike ischemia, traumatic brain injury does not result in up-regulation of the pituitary hormones PRL and GH in cerebral cortex.

• Authors: J C Goodman, L Cherian, C S Robertson
• Journal: Acta neurochirurgica. Supplement (Acta Neurochir Suppl) Vol. 102 Pg. 389-90 ( 2008) ISSN: 0065-1419 [Print] Austria
• PMID: 19388352 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• Antigens, CD34
• Glial Fibrillary Acidic Protein
• Neurofilament Proteins
• Vimentin
• Adrenocorticotropic Hormone
• Prolactin
• Growth Hormone

Topics

• Adrenocorticotropic Hormone (metabolism)
• Animals
• Antigens, CD34 (metabolism)
• Brain Injuries (metabolism, pathology)
• Disease Models, Animal
• Glial Fibrillary Acidic Protein (metabolism)
• Growth Hormone (metabolism)
• Neurofilament Proteins (metabolism)
• Prolactin (metabolism)
• Rats
• Vimentin (metabolism)