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DNA vaccination against neurite growth inhibitors to enhance functional recovery following traumatic brain injury.

AbstractBACKGROUND:
Myelin-associated proteins contribute to failure of axon regeneration in the injured central nervous system of the adult.
METHODS:
In this study, we employed a recombinant DNA vaccine encoding the myelin-derived inhibitors NogoA, myelin-associated glycoprotein (MAG) and tenascin-R (TnR), so as to effect the production of antibodies against these myelin-related antigens, in a rodent head injury model and ascertained its potential for promoting axonal plasticity and functional recovery. Adult rats underwent lateral fluid percussion at the left sensorimotor cortex (SMC) and treatment with the DNA vaccine before or after injury. Behavioral tests and neuroanatomical tract tracing was carried out.
FINDINGS:
The vaccinated rats showed improved corticorubral plasticity and functional recovery compared to control groups.
CONCLUSIONS:
This suggests that a DNA vaccination approach may provide a promising strategy for promoting repair after traumatic brain injury.
AuthorsYi Zhang, Beng Ti Ang, Zhi Cheng Xiao, Ivan Ng
JournalActa neurochirurgica. Supplement (Acta Neurochir Suppl) Vol. 102 Pg. 347-51 ( 2008) ISSN: 0065-1419 [Print] Austria
PMID19388343 (Publication Type: Journal Article)
Chemical References
  • Growth Inhibitors
  • Myelin Proteins
  • Myelin-Associated Glycoprotein
  • Nogo protein
  • Tenascin
  • Vaccines, DNA
  • tenascin R
Topics
  • Analysis of Variance
  • Animals
  • Axons (immunology, metabolism)
  • Brain Injuries (immunology, prevention & control)
  • Cerebral Cortex (drug effects, immunology, metabolism)
  • Disease Models, Animal
  • Female
  • Growth Inhibitors (genetics, immunology)
  • Myelin Proteins (genetics, immunology)
  • Myelin-Associated Glycoprotein (genetics, immunology)
  • Nerve Regeneration (drug effects, immunology)
  • Neural Pathways (drug effects, immunology, metabolism)
  • Neurologic Examination (methods)
  • Psychomotor Performance (drug effects)
  • Rats
  • Rats, Sprague-Dawley
  • Recovery of Function (drug effects, physiology)
  • Tenascin (genetics, immunology)
  • Time Factors
  • Vaccination (methods)
  • Vaccines, DNA (immunology, therapeutic use)

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