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Hydroxychavicol: a potent xanthine oxidase inhibitor obtained from the leaves of betel, Piper betle.

Abstract
The screening of Piperaceous plants for xanthine oxidase inhibitory activity revealed that the extract of the leaves of Piper betle possesses potent activity. Activity-guided purification led us to obtain hydroxychavicol as an active principle. Hydroxychavicol is a more potent xanthine oxidase inhibitor than allopurinol, which is clinically used for the treatment of hyperuricemia.
AuthorsKazuya Murata, Kikuyo Nakao, Noriko Hirata, Kensuke Namba, Takao Nomi, Yoshihisa Kitamura, Kenzo Moriyama, Takahiro Shintani, Munekazu Iinuma, Hideaki Matsuda
JournalJournal of natural medicines (J Nat Med) Vol. 63 Issue 3 Pg. 355-9 (Jul 2009) ISSN: 1861-0293 [Electronic] Japan
PMID19387769 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Enzyme Inhibitors
  • Plant Extracts
  • 2-hydroxychavicol
  • Eugenol
  • Xanthine Oxidase
Topics
  • Enzyme Inhibitors (chemistry, pharmacology)
  • Eugenol (analogs & derivatives, chemistry, pharmacology)
  • Molecular Structure
  • Piper betle (chemistry)
  • Plant Extracts (chemistry)
  • Plant Leaves (chemistry)
  • Xanthine Oxidase (antagonists & inhibitors)

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