Lymphatic vessel invasion detected by monoclonal antibody D2-40 as a predictor of lymph node metastasis in T1 colorectal cancer.

Abstract

OBJECTIVE:

When selecting patients who are at high risk for lymph node metastasis, the detection of lymphatic vessel invasion (LVI) is important. We investigated LVI detected by D2-40 staining as a predictor of lymph node metastasis in T1 colorectal cancer.

MATERIALS AND METHODS:

Clinicopathological factors including LVI were investigated in 136 patients who underwent colectomy with lymph node dissection for T1 colorectal cancer. We used immunostaining with monoclonal antibody D2-40 to detect LVI.

RESULTS:

Lymph node metastases were found in 18 patients (13.2%), and LVI were detected in 45 (33%); lymph node metastasis was more frequently observed in LVI-positive groups (13/45 vs 5/91, p < 0.001). Both univariate and multivariate analyses revealed that LVI detected by D2-40 and a poorly differentiated histology at the invasion front were independent risk factors of lymph node metastasis.

CONCLUSION:

LVI detected by D2-40 is important for the prediction of lymph node metastasis.

• Authors: M Ishii, M Ota, S Saito, Y Kinugasa, S Akamoto, I Ito
• Journal: International journal of colorectal disease (Int J Colorectal Dis) Vol. 24 Issue 9 Pg. 1069-74 (Sep 2009) ISSN: 1432-1262 [Electronic] Germany
• PMID: 19387662 (Publication Type: Journal Article)

Chemical References

• Antibodies, Monoclonal

Topics

• Antibodies, Monoclonal
• Colorectal Neoplasms (pathology)
• Female
• Humans
• Lymphatic Metastasis (diagnosis)
• Lymphatic Vessels (pathology)
• Male
• Neoplasm Invasiveness (diagnosis, immunology)
• Predictive Value of Tests