Abstract |
Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 microg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 microg/mL.
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Authors | Surat Laphookhieo, Wisanu Maneerat, Sorwaporn Koysomboon |
Journal | Molecules (Basel, Switzerland)
(Molecules)
Vol. 14
Issue 4
Pg. 1389-95
(Mar 30 2009)
ISSN: 1420-3049 [Electronic] Switzerland |
PMID | 19384270
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antimalarials
- Antineoplastic Agents, Phytogenic
- Phenols
- Plant Extracts
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Topics |
- Animals
- Antimalarials
(chemistry, pharmacology)
- Antineoplastic Agents, Phytogenic
(chemistry, pharmacology)
- Cell Line, Tumor
(drug effects)
- Clusiaceae
(anatomy & histology, chemistry)
- Drug Screening Assays, Antitumor
- Humans
- Microbial Sensitivity Tests
- Molecular Structure
- Phenols
(chemistry, pharmacology)
- Plant Bark
(chemistry)
- Plant Extracts
(chemistry)
- Plasmodium falciparum
(drug effects)
- Small Cell Lung Carcinoma
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