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Antimalarial and cytotoxic phenolic compounds from Cratoxylum maingayi and Cratoxylum cochinchinense.

Abstract
Nine phenolic compounds isolated from Cratoxylum maingayi and C. cochinchinense were evaluated for anti-malarial activity against Plasmodium falciparum, and for cytotoxic activity against the NCI-H187 (human small cell lung cancer) cancer cell line. Formoxanthone C (3) was found to be the most active against the NCI-H187 cancer cell line, with an IC(50) of 0.22 microg/mL, while vismione B (7) had the highest activity against Plasmodium falciparum, with an IC(50) of 0.66 microg/mL.
AuthorsSurat Laphookhieo, Wisanu Maneerat, Sorwaporn Koysomboon
JournalMolecules (Basel, Switzerland) (Molecules) Vol. 14 Issue 4 Pg. 1389-95 (Mar 30 2009) ISSN: 1420-3049 [Electronic] Switzerland
PMID19384270 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antimalarials
  • Antineoplastic Agents, Phytogenic
  • Phenols
  • Plant Extracts
Topics
  • Animals
  • Antimalarials (chemistry, pharmacology)
  • Antineoplastic Agents, Phytogenic (chemistry, pharmacology)
  • Cell Line, Tumor (drug effects)
  • Clusiaceae (anatomy & histology, chemistry)
  • Drug Screening Assays, Antitumor
  • Humans
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Phenols (chemistry, pharmacology)
  • Plant Bark (chemistry)
  • Plant Extracts (chemistry)
  • Plasmodium falciparum (drug effects)
  • Small Cell Lung Carcinoma

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