Abstract |
From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer.
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Authors | David Lindquist, Mircea Romanitan, Lalle Hammarstedt, Anders Näsman, Hanna Dahlstrand, Johan Lindholm, Liselotte Onelöv, Torbjörn Ramqvist, Weimin Ye, Eva Munck-Wikland, Tina Dalianis |
Journal | Molecular oncology
(Mol Oncol)
Vol. 1
Issue 3
Pg. 350-5
(Dec 2007)
ISSN: 1878-0261 [Electronic] United States |
PMID | 19383307
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Oncogene Proteins, Viral
- Papillomavirus E7 Proteins
- RNA, Messenger
- RNA, Viral
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biopsy
- Female
- Human papillomavirus 16
(genetics, metabolism)
- Humans
- Incidence
- Male
- Middle Aged
- Oncogene Proteins, Viral
(genetics)
- Papillomavirus E7 Proteins
(genetics)
- Papillomavirus Infections
(genetics, virology)
- Prognosis
- RNA, Messenger
(analysis)
- RNA, Viral
(analysis)
- Sweden
(epidemiology)
- Tonsillar Neoplasms
(epidemiology, genetics, surgery, virology)
- Viral Load
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