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Human papillomavirus is a favourable prognostic factor in tonsillar cancer and its oncogenic role is supported by the expression of E6 and E7.

Abstract
From 1970 to 2002 in the Stockholm area, we revealed a parallel three-fold increase in the incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases, indicating a possible role of HPV infection in this disease. We have now examined whether HPV and viral load in pre-treatment tonsillar cancer biopsies correlates to disease prognosis, and whether the presence of HPV-16 E6 and E7 mRNA could be ascertained. The presence of HPV-16, but not viral load, in tonsillar cancer was shown to be a favourable prognostic factor for clinical outcome. Moreover, E6 and/or E7 were expressed in almost all assessable HPV-16 positive cases, supporting an oncogenic role of HPV-16 in tonsillar cancer.
AuthorsDavid Lindquist, Mircea Romanitan, Lalle Hammarstedt, Anders Näsman, Hanna Dahlstrand, Johan Lindholm, Liselotte Onelöv, Torbjörn Ramqvist, Weimin Ye, Eva Munck-Wikland, Tina Dalianis
JournalMolecular oncology (Mol Oncol) Vol. 1 Issue 3 Pg. 350-5 (Dec 2007) ISSN: 1878-0261 [Electronic] United States
PMID19383307 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Oncogene Proteins, Viral
  • Papillomavirus E7 Proteins
  • RNA, Messenger
  • RNA, Viral
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy
  • Female
  • Human papillomavirus 16 (genetics, metabolism)
  • Humans
  • Incidence
  • Male
  • Middle Aged
  • Oncogene Proteins, Viral (genetics)
  • Papillomavirus E7 Proteins (genetics)
  • Papillomavirus Infections (genetics, virology)
  • Prognosis
  • RNA, Messenger (analysis)
  • RNA, Viral (analysis)
  • Sweden (epidemiology)
  • Tonsillar Neoplasms (epidemiology, genetics, surgery, virology)
  • Viral Load

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