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Bradykinin induces eosinophil accumulation in the rat pleural cavity.

Abstract
Intrathoracic injections of bradykinin (1-100 micrograms/cavity) induced a dose-dependent increase in the number of eosinophils recovered from the rat pleural cavity 24 h later. Eosinophilia by bradykinin was preceded by a marked pleural neutrophil influx within 6 h and was absent only 72 h following stimulation. Bradykinin (10(-9)-10(-5) M) failed to induce in vitro eosinophil chemotaxis, indicating that its in vivo effect must be mediated by an intermediate messenger. BW 755C (25 mg/kg) and the more selective lipoxygenase inhibitor BW A4C (20 micrograms/cavity) suppressed the pleural eosinophilia induced by bradykinin (50 micrograms/cavity), whereas the platelet-activating factor (PAF)-acether antagonist BN 52021 was inactive. We conclude that bradykinin is able to attract eosinophil in vivo by a mechanism independent of PAF-acether and sensitive to the blockage of the lipoxygenase pathway.
AuthorsC P Pasquale, M A Martins, P T Bozza, P M Silva, H C Faria Neto, A L Pires, R S Cordeiro
JournalInternational archives of allergy and applied immunology (Int Arch Allergy Appl Immunol) Vol. 95 Issue 2-3 Pg. 244-7 ( 1991) ISSN: 0020-5915 [Print] Switzerland
PMID1937926 (Publication Type: Journal Article)
Chemical References
  • Benzeneacetamides
  • Diterpenes
  • Ginkgolides
  • Hydroxamic Acids
  • Lactones
  • Lipoxygenase Inhibitors
  • Platelet Activating Factor
  • N-(3-phenoxycinnamyl)acetohydroxamic acid
  • 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine
  • ginkgolide B
  • Bradykinin
Topics
  • 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine (pharmacology)
  • Animals
  • Benzeneacetamides
  • Bradykinin (pharmacology)
  • Cell Movement (drug effects)
  • Chemotaxis
  • Diterpenes
  • Dose-Response Relationship, Drug
  • Eosinophilia (chemically induced, pathology)
  • Female
  • Ginkgolides
  • Hydroxamic Acids (pharmacology)
  • Injections, Intraperitoneal
  • Lactones (pharmacology)
  • Lipoxygenase Inhibitors (pharmacology)
  • Male
  • Neutrophils (physiology)
  • Platelet Activating Factor (antagonists & inhibitors, pharmacology)
  • Pleura (immunology)
  • Pleurisy (etiology)
  • Rats
  • Rats, Inbred Strains

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