Abstract | BACKGROUND: METHOD: Retrospective analysis was performed using forty-four CKD patients (chronic glomerular nephritis 16, diabetic nephropathy 9, nephrosclerosis 13, and others 6) who were treated by AST-120 during the period from October, 2001 through December, 2004 and followed up for more than 6 months. The selection criteria were an estimated creatinine clearance (eCCr) of 30 mL/min or under at the initiation of treatment and a negative change in eCCr over time (DeltaeCCr (mL/min/year)) before AST-120 treatment. The eCCr was calculated using the Cockcroft-Gault equation and the DeltaeCCr was evaluated as a marker for the progression of chronic renal failure. RESULT: Overall DeltaeCCr before and after AST-120 treatment significantly improved from -7.28 +/- 6.33 to -4.29 +/- 5.09 (paired Wilcoxon test, p < 0.05). AST-120 led to greater improvement of DeltaeCCr in patients with an DeltaeCCr of less than -10 mL/min/year before AST-120 treatment and who had higher blood uric acid, urinary protein, and urinary specific gravity valves. CONCLUSION: This finding suggests that AST-120 treatment is effective in slowing the progression of chronic kidney disease, especially, in patients who exhibit a poor response to standard care.
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Authors | Izumi Yoshida, Takanori Komada, Yuki Sakuma, Honami Mori, Izumi Funayama, Kaoru Tabei |
Journal | Nihon Jinzo Gakkai shi
(Nihon Jinzo Gakkai Shi)
Vol. 51
Issue 2
Pg. 121-9
( 2009)
ISSN: 0385-2385 [Print] Japan |
PMID | 19378798
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Angiotensin II Type 1 Receptor Blockers
- Angiotensin-Converting Enzyme Inhibitors
- Oxides
- Carbon
- AST 120
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Topics |
- Adsorption
- Angiotensin II Type 1 Receptor Blockers
(therapeutic use)
- Angiotensin-Converting Enzyme Inhibitors
(therapeutic use)
- Carbon
(administration & dosage)
- Combined Modality Therapy
- Diet, Protein-Restricted
- Diet, Sodium-Restricted
- Disease Progression
- Humans
- Kidney Failure, Chronic
(therapy)
- Life Style
- Oxides
(administration & dosage)
- Retrospective Studies
- Treatment Outcome
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