Regulators affecting the metastasis suppressor activity of Nm23-H1.

Abstract

Nm23-H1 encodes nucleoside diphosphate kinase A (NDPK-A) and is known to have a metastasis suppressive activity in many tumor cells. However, it has many other functions as well. Recent studies have shown that the interacting proteins with Nm23-H1 which mediate the cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with Nm23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of Nm23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of Nm23-H1. As a result, the interactions with Nm23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis.

• Authors: Hag Dong Kim, Buhyun Youn, Tae-Sung Kim, Sang-Hwa Kim, Hyun-Seock Shin, Joon Kim
• Journal: Molecular and cellular biochemistry (Mol Cell Biochem) Vol. 329 Issue 1-2 Pg. 167-73 (Sep 2009) ISSN: 1573-4919 [Electronic] Netherlands
• PMID: 19377884 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Carrier Proteins
• NM23 Nucleoside Diphosphate Kinases
• Neoplasm Proteins
• RNA-Binding Proteins
• STRAP protein, human
• Transcription Factors
• AURKA protein, human
• Aurora Kinase A
• Aurora Kinases
• Protein Serine-Threonine Kinases
• PRUNE1 protein, human
• Phosphoric Monoester Hydrolases
• Monomeric GTP-Binding Proteins

Topics

• Aurora Kinase A
• Aurora Kinases
• Carrier Proteins (genetics, metabolism)
• Cell Line, Tumor
• Cell Proliferation
• Gene Expression Regulation, Neoplastic
• Genes, Tumor Suppressor
• Humans
• Monomeric GTP-Binding Proteins (genetics, metabolism)
• NM23 Nucleoside Diphosphate Kinases (genetics, metabolism)
• Neoplasm Metastasis (genetics)
• Neoplasm Proteins (genetics, metabolism)
• Neoplasms (genetics)
• Phosphoric Monoester Hydrolases
• Protein Serine-Threonine Kinases (genetics, metabolism)
• RNA-Binding Proteins
• Signal Transduction (physiology)
• Transcription Factors (genetics, metabolism)