Abstract |
In order to study the capacity of antioxidants and high-density lipoproteins (HDL) to modulate the effects of low-density lipoprotein ( LDL) on intercellular communication, arterial smooth muscle cells and a dye transfer method were used. LDL, in contrast to HDL, inhibited the communication between arterial smooth muscle cells from human umbilical cord and thoracic aorta in a dose-dependent manner. LDL, which can be oxidized, as detected by the lipid-peroxidation assay and gel electrophoresis, did not influence cell-cell communication in the presence of the antioxidants butylated hydroxytoluene ( BHT), alpha-tocopherol and glutathione. The results suggest that LDL must undergo oxidative modification before it can influence intercellular communication. Like antioxidants, HDL diminished the LDL-induced inhibition of cell-cell communication. This study suggests that the modulation of gap-junctional communication by the balance of HDL and LDL in plasma may influence atherogenesis.
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Authors | R M Zwijsen, L H de Haan, J A Kuivenhoven, I C Nusselder |
Journal | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
(Food Chem Toxicol)
Vol. 29
Issue 9
Pg. 615-20
(Sep 1991)
ISSN: 0278-6915 [Print] England |
PMID | 1937292
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Lipoproteins, HDL
- Lipoproteins, LDL
- Vitamin E
- Butylated Hydroxytoluene
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Topics |
- Antioxidants
(pharmacology)
- Arteriosclerosis
(etiology)
- Butylated Hydroxytoluene
(pharmacology)
- Cell Communication
(drug effects)
- Cells, Cultured
- Humans
- Lipoproteins, HDL
(pharmacology)
- Lipoproteins, LDL
(pharmacology)
- Male
- Middle Aged
- Vitamin E
(pharmacology)
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