Carcinogenicity study of cochineal in B6C3F1 mice.

Abstract

The carcinogenicity of cochineal, a red colouring used in food and other products, was studied in a 2-yr bioassay in B6C3F1 mice. Groups of 50-55 mice of each sex were given 0, 3 or 6% cochineal in the diet for 2 yr. Mice of all groups developed tumours including hepatocellular adenomas or carcinomas, pulmonary adenomas or adenocarcinomas and lymphomas or lymphatic leukaemias, and the incidences of these tumours were not significantly different in treated and control groups. The results indicate that cochineal lacks carcinogenicity in mice and are consistent with those of in vitro short-term assays of cochineal and of carminic acid, an active principle of cochineal.

• Authors: H Mori, H Iwata, T Tanaka, Y Morishita, Y Mori, T Kojima, A Okumura
• Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 29 Issue 9 Pg. 585-8 (Sep 1991) ISSN: 0278-6915 [Print] England
• PMID: 1937288 (Publication Type: Journal Article)

Chemical References

• Food Coloring Agents
• Carmine

Topics

• Animals
• Carmine (analogs & derivatives, toxicity)
• Female
• Food Coloring Agents (toxicity)
• Male
• Mice
• Mice, Inbred Strains
• Neoplasms, Experimental (chemically induced)