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Differential expression of microtubule-associated protein 2 in melanocytic skin lesions.

Abstract
Neoplastic melanocytes may exhibit certain differentiation characteristics of other neural-crest derivatives. We aimed to study the expression of microtubule-associated protein 2 (MAP-2) in different types of melanocytic skin lesions. Paraffin-embedded sections of 42 benign nevi (BN), 22 dysplastic nevi (DN), 45 superficial spreading melanomas (SSMs), and 15 subcutaneous melanoma metastases were immunohistologically assessed using the monoclonal mouse MAP-2ab antibody (Zytomed, Berlin, Germany). The percentage MAP-2 expression of DN and SSMs was significantly increased compared with BN. Moreover, subcutaneous melanoma metastases showed significantly decreased MAP-2 expression compared with DN and SSMs. In SSMs, MAP-2 expression significantly correlated with the Breslow vertical tumor thickness, Clark level, and stage of disease. We observed that MAP-2 is differentially expressed during the development and progression of benign and malignant melanocytic skin lesions. In contrast with the findings of previous studies, our data indicate that MAP-2 is a moderately positive predictor of the progression of SSMs.
AuthorsThilo Gambichler, Sebastian Rotterdam, Katharina Radkowski, Peter Altmeyer, Alexander Kreuter
JournalAmerican journal of clinical pathology (Am J Clin Pathol) Vol. 131 Issue 5 Pg. 710-4 (May 2009) ISSN: 1943-7722 [Electronic] England
PMID19369632 (Publication Type: Journal Article)
Chemical References
  • Biomarkers, Tumor
  • MAP2 protein, human
  • Microtubule-Associated Proteins
Topics
  • Biomarkers, Tumor (metabolism)
  • Disease Progression
  • Dysplastic Nevus Syndrome (metabolism, pathology)
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Melanocytes (metabolism, pathology)
  • Melanoma (metabolism, secondary)
  • Microtubule-Associated Proteins (metabolism)
  • Middle Aged
  • Neoplasm Staging
  • Nevus, Pigmented (metabolism, pathology)
  • Skin Neoplasms (metabolism, pathology)

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