Abstract | OBJECTIVE: METHODS: We retrospectively evaluated 124 consecutive patients with first-ever acute lacunar infarctions who were admitted to our hospital within 24 hours after the onset between January 2004 and June 2007. Of these, 59 patients received both edaravone and conventional therapy ( edaravone group), and the other 65 underwent conventional therapy only (non- edaravone group). There was no significant difference in patients' baseline characteristics in the two groups. The clinical outcome was assessed by the National Institutes of Health Stroke Scale (NIHSS). RESULTS: The reduction of NIHSS scale during hospitalization (1.5+/-1.0 vs. 1.0+/-1.1; p = 0.007), especially that of the motor palsy scale (1.0+/-1.0 vs. 0.5+/-1.0; p = 0.006) was significantly larger, and the percentage of patients with a favorable outcome (NIHSS at discharge < or =1) (91.5% vs. 78.5%; p = 0.044) was significantly better in the edaravone group. CONCLUSION:
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Authors | Yasuyuki Ohta, Kazuhiro Takamatsu, Tomoko Fukushima, Satomi Ikegami, Ikuko Takeda, Taisei Ota, Katsuya Goto, Koji Abe |
Journal | Internal medicine (Tokyo, Japan)
(Intern Med)
Vol. 48
Issue 8
Pg. 593-6
( 2009)
ISSN: 1349-7235 [Electronic] Japan |
PMID | 19367054
(Publication Type: Journal Article)
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Chemical References |
- Free Radical Scavengers
- Edaravone
- Antipyrine
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Topics |
- Aged
- Antipyrine
(analogs & derivatives, therapeutic use)
- Brain Infarction
(complications)
- Edaravone
- Female
- Free Radical Scavengers
(therapeutic use)
- Humans
- Male
- Middle Aged
- Paralysis
(drug therapy, etiology)
- Regression Analysis
- Retrospective Studies
- Treatment Outcome
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