Association between circulating soluble receptor for advanced glycation end products and atherosclerosis: observations from the Dallas Heart Study.

Abstract

OBJECTIVE:

To determine the association between circulating soluble receptor for advanced glycation end products (sRAGE) and coronary atherosclerosis.

RESEARCH DESIGN AND METHODS:

Using data from the Dallas Heart Study, a probability-based population sample, the association between plasma levels of sRAGE and coronary artery calcium (CAC) was assessed among 2,571 subjects with complete imaging and sRAGE data.

RESULTS:

An inverse graded association was observed between sRAGE quartiles and CAC, with CAC prevalence of 28.5% in quartile 1 compared with 15.7% in quartile 4 (P < 0.0001). After multivariable adjustment, the associations between sRAGE levels in the first and second quartiles (versus fourth quartile) and CAC remained statistically significant (adjusted odds ratio 1.71 [95% CI 1.2-2.4] and 1.5 [1.0-2.1], respectively).

CONCLUSIONS:

sRAGE is a novel biomarker that is inversely associated with coronary atherosclerosis. The role of sRAGE in the pathobiology of atherosclerosis and its potential prognostic and therapeutic implications warrant further investigation.

• Authors: Jason B Lindsey, James A de Lemos, Francesco Cipollone, Colby R Ayers, Anand Rohatgi, David A Morrow, Amit Khera, Darren K McGuire
• Journal: Diabetes care (Diabetes Care) Vol. 32 Issue 7 Pg. 1218-20 (Jul 2009) ISSN: 1935-5548 [Electronic] United States
• PMID: 19366975 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Receptor for Advanced Glycation End Products
• Receptors, Immunologic
• Calcium

Topics

• Adult
• Atherosclerosis (blood)
• Calcium (blood)
• Coronary Vessels (metabolism)
• Female
• Humans
• Male
• Odds Ratio
• Racial Groups
• Receptor for Advanced Glycation End Products
• Receptors, Immunologic (blood)
• Texas