Tolerability of clindamycin/tretinoin gel vs. tretinoin microsphere gel and adapalene gel.

Abstract

BACKGROUND:

Newer agents and formulations seek to improve the tolerability of topical retinoid therapy. Recently, a gel containing crystalline clindamycin 1.2% and tretinoin 0.025% (CLIN/RA) was approved by the U.S. Food and Drug Administration (FDA) for the treatment of treating mild-to-moderate acne.

OBJECTIVE:

This single-center, randomized, evaluator-blind phase 1 study compared the tolerability of CLIN/RA to 0.1% tretinoin gel or 0.1% adapalene gel.

RESULTS:

Forty-five patients applied CLIN/RA once daily to one side of their face every day for 21 days. Patients were randomized to either tretinoin 0.1% (n = 23) or adapalene 0.1% (n = 22) on the contralateral side. A clinical evaluator assessed degree of erythema and scaling; patients provided subjective evaluations of burning, stinging, and itching.

CONCLUSION:

CLIN/RA was significantly better tolerated than was 0.1% tretinoin gel, as evidenced by significantly reduced erythema (P < 0.04), scaling (P < 0.03), itching (P < 0.02), burning (P < 0.03) and stinging (P < 0.04). A trend for greater erythema, scaling, and subjective discomfort for 0.1% adapalene gel compared to CLIN/RA was also evident.

• Authors: James Leyden, Mitchell Wortzman, Edward K Baldwin
• Journal: Journal of drugs in dermatology : JDD (J Drugs Dermatol) Vol. 8 Issue 4 Pg. 383-8 (Apr 2009) ISSN: 1545-9616 [Print] United States
• PMID: 19363857 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Anti-Bacterial Agents
• Dermatologic Agents
• Drug Combinations
• Gels
• Naphthalenes
• Adapalene
• Clindamycin
• Tretinoin

Topics

• Acne Vulgaris (drug therapy)
• Adapalene
• Adolescent
• Adult
• Anti-Bacterial Agents (administration & dosage, adverse effects)
• Clindamycin (administration & dosage, adverse effects)
• Dermatologic Agents (administration & dosage, adverse effects)
• Drug Combinations
• Female
• Gels
• Humans
• Male
• Microspheres
• Naphthalenes (administration & dosage, adverse effects)
• Tretinoin (administration & dosage, adverse effects)
• Young Adult