Mirtazapine in an HIV-1 infected patient with progressive multifocal leukoencephalopathy.

Abstract

We describe the clinical course of an HIV-infected patient with progressive multifocal leukoencephalopathy who took mirtazapine for his depression. After six months of therapy the clinical symptoms had not worsened and the neuroradiological image of the brain was unchanged. Further studies are necessary to determine the effect of serotonin receptor antagonist in treating PML associated to HIV.

• Authors: M Lanzafame, S Ferrari, E Lattuada, F Corsini, R Deganello, S Vento, E Concia
• Journal: Le infezioni in medicina (Infez Med) Vol. 17 Issue 1 Pg. 35-7 (Mar 2009) ISSN: 1124-9390 [Print] Italy
• PMID: 19359824 (Publication Type: Case Reports, Journal Article)

Chemical References

• Mianserin
• Mirtazapine

Topics

• AIDS-Related Opportunistic Infections (drug therapy)
• Acquired Immunodeficiency Syndrome (drug therapy)
• Antiretroviral Therapy, Highly Active
• HIV-1
• Humans
• JC Virus (drug effects, physiology)
• Leukoencephalopathy, Progressive Multifocal (drug therapy, pathology, virology)
• Magnetic Resonance Imaging
• Meningitis, Cryptococcal (complications)
• Mianserin (analogs & derivatives, pharmacology, therapeutic use)
• Mirtazapine
• Virus Internalization (drug effects)