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Diagnosis of tuberculous pleural effusion by the detection of tuberculostearic acid in pleural aspirates.

AbstractDetection of TBSA was attempted in pleural aspirates of 74 patients with tuberculous and 44 patients with nontuberculous pleural effusion by gas chromatography/mass spectrometry with selected ion monitoring. The results were disappointing with a test sensitivity of 67.6 percent and a specificity of 52.3 percent. In contrast, histologic examination of pleural biopsies gave a diagnostic sensitivity of 71.0 percent. Pleural biopsy remains a better investigational procedure for the diagnosis of tuberculous pleural effusion.
AuthorsW W Yew, C Y Chan, S Y Kwan, S W Cheung, G L French (Affiliation: Tuberculosis and Chest Unit, Grantham Hospital, Aberdeen, Hong Kong.)
JournalChest (Chest) Vol. 100 Issue 5 Pg. 1261-3 (Nov 1991) ISSN: 0012-3692 [Print] UNITED STATES
PMID1935278 (Publication Type: Journal Article)
Chemical References
  • Stearic Acids
  • tuberculostearic acid
Topics
  • Biopsy
  • Humans
  • Pleura (pathology)
  • Pleural Effusion (diagnosis, etiology, pathology)
  • Predictive Value of Tests
  • Prospective Studies
  • Sensitivity and Specificity
  • Sputum (microbiology)
  • Stearic Acids (analysis)
  • Tuberculosis, Pleural (complications, diagnosis, pathology)

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