F-18 FDG PET-CT findings in Mikulicz disease and systemic involvement of IgG4-related lesions.

Abstract

A 72-year-old woman with Mikulicz disease with pathogically proven sclerosing sialadenitis showed systemic abnormal F-18 FDG uptake in the bilateral lacrimal and submandibular glands, pancreas, abdominal aortic wall, and a retroperitoneal fibroid mass on PET/CT scan, with marked elevation of the serum IgG4 level. This case supports Mikulicz disease being included as 1 of the disorders associated with a new clinical entity of systemic IgG4-related plasmacytic syndrome. A whole-body FDG-PET/CT scan can be expected as a useful tool for detecting systemic involvement in systemic IgG4-related plasmacytic syndrome.

• Authors: Kazuyoshi Suga, Yasuhiko Kawakami, Atsuto Hiyama, Kenji Hori, Megumi Takeuchi
• Journal: Clinical nuclear medicine (Clin Nucl Med) Vol. 34 Issue 3 Pg. 164-7 (Mar 2009) ISSN: 1536-0229 [Electronic] United States
• PMID: 19352281 (Publication Type: Case Reports, Journal Article)

Chemical References

• Immunoglobulin G
• Fluorodeoxyglucose F18

Topics

• Aged
• Female
• Fluorodeoxyglucose F18 (metabolism)
• Humans
• Immunoglobulin G (blood)
• Mikulicz' Disease (blood, diagnostic imaging, pathology)
• Plasma Cells (diagnostic imaging, pathology)
• Positron-Emission Tomography
• Tomography, X-Ray Computed