Involvement of hypothalamic glutamate in cisplatin-induced emesis in Suncus murinus (house musk shrew).

Abstract

We investigated the effect of cisplatin on glutamate release in the hypothalamus of Suncus murinus measured by brain microdialysis. Dialysis samples were collected every 20 min for 1 h before and 3 h after the cisplatin (30 mg/kg, i.p.) administration with the animals also being observed for the development of emesis. Cisplatin increased glutamate levels within 1 h and this was closely associated with the occurrence of emesis. Pretreatment with the 5-HT(3)-receptor antagonist ondansetron (2 mg/kg, i.p.) inhibited both the emesis and the increased glutamate levels. These results suggest that hypothalamic glutamate is involved in cisplatin-induced emesis in Suncus murinus.

• Authors: Kouichi Yamamoto, Sze Wa Chan, John A Rudd, Ge Lin, Keiko Asano, Atsushi Yamatodani
• Journal: Journal of pharmacological sciences (J Pharmacol Sci) Vol. 109 Issue 4 Pg. 631-4 (Apr 2009) ISSN: 1347-8613 [Print] Japan
• PMID: 19352072 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antiemetics
• Antineoplastic Agents
• Glutamic Acid
• Ondansetron
• Cisplatin

Topics

• Animals
• Antiemetics (therapeutic use)
• Antineoplastic Agents
• Brain (pathology)
• Cisplatin
• Female
• Glutamic Acid (physiology)
• Hypothalamus (drug effects, metabolism)
• Immunohistochemistry
• Microdialysis
• Ondansetron (therapeutic use)
• Shrews (physiology)
• Vomiting (chemically induced, drug therapy, physiopathology)