Abstract | PURPOSE: Surgical stress has been suggested to facilitate the growth of preexisting micrometastases as well as small residual tumor postoperatively. The purpose of this study was to examine the effects of surgical stress on ovarian cancer growth and to determine underlying mechanisms responsible for increased growth. EXPERIMENTAL DESIGN: To mimic the effects of surgery, we did a laparotomy or mastectomy under isoflurane inhalation on athymic nude mice 4 days after i.p. tumor cell injection. Propranolol infusion via Alzet pumps was used to block the influence of sympathetic nervous system activation by surgical stress. RESULTS: CONCLUSION: These results indicate that surgical stress could enhance tumor growth and angiogenesis, and beta-blockade might be effective in preventing such effects.
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Authors | Jeong-Won Lee, Mian M K Shahzad, Yvonne G Lin, Guillermo Armaiz-Pena, Lingegowda S Mangala, Hee-Dong Han, Hye-Sun Kim, Eun Ji Nam, Nicholas B Jennings, Jyotsnabaran Halder, Alpa M Nick, Rebecca L Stone, Chunhua Lu, Susan K Lutgendorf, Steve W Cole, Anna E Lokshin, Anil K Sood |
Journal | Clinical cancer research : an official journal of the American Association for Cancer Research
(Clin Cancer Res)
Vol. 15
Issue 8
Pg. 2695-702
(Apr 15 2009)
ISSN: 1078-0432 [Print] United States |
PMID | 19351748
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Adrenergic beta-Antagonists
- Cytokines
- Platelet Endothelial Cell Adhesion Molecule-1
- Proliferating Cell Nuclear Antigen
- Receptors, Adrenergic, beta
- Vascular Endothelial Growth Factor A
- Propranolol
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Topics |
- Adrenergic beta-Antagonists
(pharmacology)
- Animals
- Carcinoma
(metabolism, pathology, surgery)
- Cell Line, Tumor
- Cell Proliferation
- Cytokines
(blood)
- Female
- Humans
- Mice
- Mice, Nude
- Microvessels
(drug effects, pathology, physiology)
- Neovascularization, Pathologic
(pathology)
- Ovarian Neoplasms
(metabolism, pathology, surgery)
- Platelet Endothelial Cell Adhesion Molecule-1
(metabolism)
- Proliferating Cell Nuclear Antigen
(metabolism)
- Propranolol
(pharmacology)
- Receptors, Adrenergic, beta
(drug effects, metabolism)
- Stress, Psychological
(pathology)
- Transplantation, Heterologous
(pathology)
- Vascular Endothelial Growth Factor A
(antagonists & inhibitors, metabolism)
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