Abstract |
Euxyl K 400 is a preservative for cosmetics and toiletries containing 2 active ingredients, 1,2-dibromo-2,4-dicyanobutan and 2-phenoxyethanol. 2057 consecutive patients with contact dermatitis were patch tested with Euxyl K 400 2.5% pet. and ethanol. A positive patch test occurred in 24 patients (1.2%). The source of sensitization was traced in 8 patients to their cosmetics. Both leave-on and rinse-off products were responsible. Further patch tests with Euxyl K 400 0.5% pet. and phenoxyethanol 5% pet. were performed in 11 patients. A positive patch test to phenoxyethanol was detected in 1 of them. Only 3 patients showed a mild reaction to Euxyl K 400 0.5%. A provocative use test with a lotion preserved with Euxyl K 400 0.1% was positive in 5 of these 11 patients. Patients with Euxyl K 400 sensitivity showed a high prevalence of positive patch tests to other common ingredients of cosmetics. Since the use of Euxyl K 400 in cosmetic products is rapidly increasing, it should be included in the patch test series for patients with suspected cosmetic allergy.
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Authors | A Tosti, L Guerra, F Bardazzi, F Gasparri |
Journal | Contact dermatitis
(Contact Dermatitis)
Vol. 25
Issue 2
Pg. 89-93
(Aug 1991)
ISSN: 0105-1873 [Print] England |
PMID | 1935053
(Publication Type: Journal Article)
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Chemical References |
- Anti-Infective Agents, Local
- Cosmetics
- Ethylene Glycols
- Nitriles
- Preservatives, Pharmaceutical
- phenoxyethanol
- 1,2-dibromo-2,4-dicyanobutane
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Infective Agents, Local
(adverse effects)
- Child
- Cosmetics
(adverse effects)
- Dermatitis, Contact
(etiology)
- Ethylene Glycols
(adverse effects)
- Facial Dermatoses
(chemically induced)
- Female
- Humans
- Male
- Middle Aged
- Nitriles
(adverse effects)
- Preservatives, Pharmaceutical
(adverse effects)
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