Experimental study of the potential for contact sensitization and cross-reaction of imidazole antifungals.

Abstract

We examined the potential for contact sensitization of miconazole nitrate and croconazole hydrochloride and the cross-reaction between them in guinea pigs by the maximization test of Magnusson and Kligman. Contact sensitivity was induced by croconazole hydrochloride in 5 out of 7 animals which, after being injected with 5% croconazole hydrochloride, underwent a closed patch with 25% croconazole hydrochloride. Contact sensitivity was not induced by miconazole nitrate. The 5 animals sensitized to croconazole hydrochloride were tested with 8 other imidazole antifungals and positive reactions were observed to oxiconazole nitrate in 2 of the 5 animals. This response may be a cross-reaction.

• Authors: K Nishioka, K Kurata, C Asagami
• Journal: Contact dermatitis (Contact Dermatitis) Vol. 25 Issue 1 Pg. 39-44 (Jul 1991) ISSN: 0105-1873 [Print] England
• PMID: 1935032 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Imidazoles
• croconazole
• imidazole
• Miconazole

Topics

• Animals
• Antifungal Agents (adverse effects, immunology)
• Cross Reactions
• Dermatitis, Contact (etiology, immunology)
• Female
• Guinea Pigs
• Imidazoles (adverse effects)
• Injections, Intradermal
• Miconazole (adverse effects)
• Patch Tests