No relationship between 2',3'-cyclic nucleotide 3'-phosphodiesterase and schizophrenia in the Chinese Han population: an expression study and meta-analysis.

Abstract

BACKGROUND:

2',3'-Cyclic nucleotide 3'-phosphodiesterase (CNP), one of the promising candidate genes for schizophrenia, plays a key part in the oligodendrocyte function and in myelination. The present study aims to investigate the relationship between CNP and schizophrenia in the Chinese population and the effect of different factors on the expression level of CNP in schizophrenia.

METHODS:

Five CNP single nucleotide polymorphisms (SNPs) were investigated in a Chinese Han schizophrenia case-control sample set (n = 180) using direct sequencing. The results were included in the following meta-analysis. Quantitative real-time polymerase chain reaction (PCR) was conducted to examine CNP expression levels in peripheral blood lymphocytes.

RESULTS:

Factors including gender, genotype, sub-diagnosis and antipsychotics-treatment were found not to contribute to the expression regulation of the CNP gene in schizophrenia. Our meta-analysis produced similar negative results.

CONCLUSION:

The results suggest that the CNP gene may not be involved in the etiology and pathology of schizophrenia in the Chinese population.

• Authors: Ronglin Che, Wei Tang, Jing Zhang, Zhiyun Wei, Zhao Zhang, Ke Huang, Xinzhi Zhao, Jianjun Gao, Guoquan Zhou, Peirong Huang, Lin He, Yongyong Shi
• Journal: BMC medical genetics (BMC Med Genet) Vol. 10 Pg. 31 (Apr 06 2009) ISSN: 1471-2350 [Electronic] England
• PMID: 19348671 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphoric Diester Hydrolases
• 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
• CNP protein, human

Topics

• 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase
• Adult
• Alleles
• Asian People (genetics)
• Case-Control Studies
• China
• Female
• Gene Expression
• Gene Frequency
• Genetic Predisposition to Disease
• Genotype
• Haplotypes
• Humans
• Linkage Disequilibrium
• Male
• Middle Aged
• Phosphoric Diester Hydrolases (genetics)
• Polymorphism, Single Nucleotide
• Reverse Transcriptase Polymerase Chain Reaction
• Schizophrenia (enzymology, genetics)