[Effect of Alinamin F and Kakkontou on mucoid Pseudomonas aeruginosa chronic lower respiratory tract infection].

Abstract

In a 78-year-old woman with chronic respiratory tract infection caused by Pseudomonas aeruginosa with a mucoid phenotype, the organism was eliminated from the sputum by use of Kakkontou (Chinese herbal drug) and Alinamin F (Fursultiamine). Gram staining of a sputum smear showed mucoid micro-organisms were engulfed by neutrophils. Both drugs could change the mucoid character of this microorganism. It was suggested that polymorphonuclear leukocytes activated by Kakkontou could recognize this organism as a foreign body because of the changed mucoid character, and cleared it by phagocytosis.

• Authors: Kenji Irifune
• Journal: Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society (Nihon Kokyuki Gakkai Zasshi) Vol. 47 Issue 3 Pg. 218-21 (Mar 2009) ISSN: 1343-3490 [Print] Japan
• PMID: 19348269 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Drugs, Chinese Herbal
• kakkon-to
• prosultiamine
• Thiamine

Topics

• Aged
• Chronic Disease
• Drugs, Chinese Herbal (therapeutic use)
• Female
• Humans
• Pseudomonas Infections (drug therapy)
• Respiratory Tract Infections (drug therapy)
• Thiamine (analogs & derivatives, therapeutic use)