Indomethacin-induced colon perforation in Bartter's syndrome.

Abstract

Bartter's syndrome (BS) is an inherited renal tubular disorder characterized by hypokalemia, hypochloremic metabolic alkalosis, and hyperaldosteronism with normal blood pressure. A 22-year-old woman was referred at 23 week of gestation. Polyhydramnios was detected and the chloride level of the amniotic fluid was high. The mother was treated with indomethacin from 26 to 31 week of gestation. The newborn was delivered at 34 week of gestation. At 8th day of life, indomethacin was also started for the baby. After three days, a colonic perforation developed. Indomethacin-induced colon perforation is uncommon in antenatal Bartter's syndrome. This patient indicates that administration of indomethacin in both antenatal and/or early postnatal period may be associated with colonic perforation.

• Authors: Emel Ataoglu, Mahmut Civilibal, Ayse Ayaz Ozkul, Ipek Guney Varal, Elmas Reyhan Oktay, Elevli Murat
• Journal: Indian journal of pediatrics (Indian J Pediatr) Vol. 76 Issue 3 Pg. 322-3 (Mar 2009) ISSN: 0973-7693 [Electronic] India
• PMID: 19347676 (Publication Type: Case Reports, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Indomethacin

Topics

• Adult
• Amniotic Fluid (chemistry)
• Anti-Inflammatory Agents, Non-Steroidal (adverse effects)
• Bartter Syndrome (complications, diagnosis, drug therapy, genetics)
• Colonic Diseases (complications, genetics)
• Female
• Gestational Age
• Humans
• Indomethacin (adverse effects)
• Infant, Newborn
• Intestinal Perforation (chemically induced, complications, genetics)
• Mutation
• Polyhydramnios (drug therapy, genetics)
• Pregnancy
• Pregnancy Complications (genetics)