| Abstract | Inhaled corticosteroids (ICSs) are considered the most effective therapy currently available for persistent asthma and is the guideline-recommended first-line treatment for all patients requiring controller medication; however, the potential for oropharyngeal and systemic adverse events can be a barrier to their use. Ciclesonide (CIC) is a new ICS with a unique pharmacologic profile that may confer a favorable safety profile. This study was designed to provide a comprehensive review of currently available safety data for CIC in adults and children with asthma of all severities. The literature was reviewed for all clinical trials with CIC reporting safety results (no date restrictions; English language only). Clinical trials with CIC in children and adults showed a very low occurrence of oropharyngeal adverse events (including oral candidiasis, pharyngitis, and hoarseness) and minimal systemic activity. In particular, no clinically relevant effect on cortisol levels was observed, compared with placebo or active comparators, even with high-dose CIC treatment (up to 1280 microg/day) and in asthma of all severities. Furthermore, there was no clinically relevant effect of CIC treatment on growth in children with mild asthma compared with placebo. The favorable safety profile of CIC may allay patient and physician concern regarding ICS when using this agent. Guideline-recommended use of ICS medications may help optimize treatment outcomes in asthma. |
| Authors | Timothy Craig
(Affiliation: Department of Medicine and Pediatrics, Penn State University, College of Medicine, Hershey, Pennsylvania 17033, USA. tcraig at psu.edu)
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| Journal | Allergy and asthma proceedings : the official journal of regional and state allergy societies
(Allergy Asthma Proc)
2009 May-Jun
Vol. 30
Issue 3
Pg. 315-24
ISSN: 1088-5412 [Print] United States |
| PMID | 19344547
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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| Chemical References |
- Anti-Allergic Agents
- Pregnenediones
- ciclesonide
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| Topics |
- Anti-Allergic Agents
(administration & dosage, adverse effects, therapeutic use)
- Asthma
(drug therapy, immunology)
- Clinical Trials as Topic
- Humans
- Practice Guidelines as Topic
- Pregnenediones
(administration & dosage, adverse effects, therapeutic use)
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