Antiviral activity of polyoxomolybdoeuropate PM-104 against human immunodeficiency virus type 1.

Abstract

A polyoxomolybdoeuropate PM-104 (NH4)12H2[Eu4(MoO4)(H2O)16(Mo7O24)4].13H2O was found to be a potent inhibitor of the growth of human immunodeficiency virus type 1 (HIV-1), a causative agent of acquired immunodeficiency syndrome (AIDS). On the basis of TI50 [median cytotoxic concentration (CC50)/median effective concentration (EC50)], the in vitro anti-HIV-1 activity of PM-104 is favorably comparable to that of a heteropolyoxotungstate PM-19 K7[PTi2W10O40].6H2O, which is one of the most potent HIV-1 inhibitors among the polyoxometalates so far tested. The heteropolyoxomolybdate with a potent anti-HIV-1 activity is introduced for the first time in this communication.

• Authors: Y Inouye, Y Tokutake, T Yoshida, A Yamamoto, T Yamase, S Nakamura
• Journal: Chemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 39 Issue 6 Pg. 1638-40 (Jun 1991) ISSN: 0009-2363 [Print] Japan
• PMID: 1934191 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Organometallic Compounds
• PM 104

Topics

• Antiviral Agents (pharmacology)
• Cells, Cultured
• HIV-1 (drug effects)
• Organometallic Compounds (pharmacology)